Level 5 Networks, a leading developer of high-speed server interconnect solutions, announced that University of Nottingham School of Pharmacy has deployed Level 5 Networks' EtherFabric to eliminate the interconnect processing bottleneck in its high-performance computing (HPC) cluster used to conduct biophysics research. After simply replacing eight out of 16 existing Ethernet cards -- without any other hardware or software changes -- the researchers experienced a 300 percent increase in performance. Such performance enhancements significantly speed time to market in clinical trials, getting medicines out to the masses that need them sooner, and can also reduce a project's overhead and operational costs. The research is conducted on a 16-node satellite clone of a larger computing cluster comprising 512 Sun V20z nodes, each with two AMD Opteron 248 CPUs, running SUSE Professional Linux 9.0. The research work conducted by the Laboratory of Biophysics and Surface Analysis (LBSA) at Nottingham University involves the "folding" nature of proteins and has the potential to lead to important discoveries in the areas of diabetes, Alzheimer's disease, and other ailments. The research cluster runs standard versions of molecular engineering and simulation applications including AMBER, CHARMM and Moil. Prior to deploying EtherFabric, all the nodes were connected using motherboard gigabit interconnects. As the number of parallel processes increased, however, CPU performance degraded, seriously slowing down research. "We buy computers to do calculations, not to run networks, but with standard Ethernet, our CPUs simply choked on the high transaction rate and the massive amount of data our research involved," said Dr. Phil Williams, an Advanced Research Fellow in Theoretical Biophysics at the School of Pharmacy, University of Nottingham. "The beauty of EtherFabric is that we were able to install it by simply replacing a card and installing a driver. No new cables. No changes to applications. No problems. And after upgrading only eight of our 16 nodes with EtherFabric, we saw an immediate 300 percent increase in performance, leading to some stunning benefits." The benefits include enabling the University to do three times the work using the same resources. And this time is precious. With typical pharmaceutical drugs, each day saved in development is worth over $1 million in costs. With three times the performance, the University's running costs for each job (electricity, air conditioning, and maintenance) have been reduced significantly, providing both financial and environmental benefits. In a shared computing environment using multiple-CPU nodes, where multiple researchers rely on the same resources, removing the system overhead for networking from the CPU reduces the impact of one job on another. "Whether the goal is greater throughput for high-performance computing applications or increased speed for data center operations, IT managers need to hit their targets without the high cost and risk of ripping out their infrastructure, recompiling their applications or updating their operating system," said Dan Karr, President and CEO of Level 5 Networks. "EtherFabric is the only solution that is fully system compatible, which means that any networked computing environment can easily and cost-effectively achieve significant performance gains."