German physicist Schölkopf wins 2019 Körber Prize of one million euros

The 2019 Körber European Science Prize, endowed with one million euros, is to be awarded to the German physicist, mathematician and computer scientist Bernhard Schölkopf. He has developed mathematical methods that have made a significant contribution to helping artificial intelligence (AI) reach its most recent heights. Schölkopf achieved worldwide renown with support-vector machines (SVMs). These are not machines in the classical sense, but sophisticated algorithms (program instructions) with which computers can perform highly complicated AI calculations quickly and precisely.

Bernhard Schölkopf, 51, is a pioneer of this new industrial revolution based on information. After studying physics, mathematics, and philosophy in Tübingen and London, the Stuttgart native went on a scholarship to the American Bell Labs, where his subsequent Ph.D. supervisor Vladimir Vapnik was just beginning to conduct research into SVMs. In 1997, Schölkopf received his doctorate in computer science from the TU Berlin. He already contributed decisively to the development of SVM technology to application maturity in the Vapnik team. After working in Cambridge, England, and at a New York biotech start-up, Schölkopf became Director of the Max Planck Institute (MPI) for Biological Cybernetics in Tübingen in 2001. In 2011, he was one of the founding directors of the MPI for Intelligent Systems in Tübingen. {module In-article}

Although almost everyone comes into contact with it on a daily basis, around half of Germans do not know what exactly is meant by the term "artificial intelligence". "AI is in play when a smartphone automatically groups stored photos according to faces and topics such as holidays," explains Schölkopf, "or translates texts from one language into another."

AI is currently experiencing a global boom, not least because of its growing economic importance. The USA and China are investing billions in this technology, which is likely to fundamentally change working life throughout the world. Even before the turn of the millennium, intelligent robots were moving into factories on a large scale, for example in the automotive industry. In the future, intelligent systems will increasingly take over routine tasks in offices.

The support-vector machines co-developed by Bernhard Schölkopf are similar to neural networks modeled on the brain, but provide more precise results for some tasks. In addition, they are based on solid mathematical principles, which makes their mode of operation more transparent. SVMs initially need to be trained, just as the human brain does when learning. Their special attribute is that their algorithms make clean-cut classifications in mathematical spaces of higher dimensions, but the computer can do this with comparatively simple and fast calculations.

The first SVM systems from the 1990s were able to recognize handwritten numbers on letters almost as well as humans and were better than any competing systems. They also gave a significant boost to computer science because of their systematic mathematical approach. Schölkopf is today's most frequently cited German computer scientist and, according to the research magazine "Science", ranks among the ten most influential computer scientists in the world.

The Schölkopf team at the MPI Tübingen is currently investigating algorithms that can also identify causal relationships from data. This promising new field of research is referred to as causal inference. One of its goals is to make AI systems more robust against interference. "If in a built-up area, a 30 km/h speed limit sign has been passed over in such a way that it looks like a 120 km/h sign, then the AI system of a driverless car must be able to infer from the context that this sign is to be ignored," says Bernhard Schölkopf.

Another of Schölkopf's concern is to help Germany achieve a leading position in the tough international competition for AI. He is the co-founder of the world-renowned "Cyber Valley" in the Stuttgart-Tübingen region – a center of excellence funded by the state of Baden-Württemberg that has also been able to integrate leading American companies. As part of the planned ELLIS program (European Laboratory for Learning and Intelligent Systems), Schölkopf hopes to "better network leading European locations, set up joint programs and train doctoral students. Young top researchers should not have to go to the USA to work at the highest level". In addition, it is important to have even more extensive state AI funding. Schölkopf intends to use the funds of the Körber Prize in his Causal Inference area of expertise and for workshops to promote the ELLIS project.

The Körber European Science Prize 2019 will be presented to Bernhard Schölkopf on 13 September in the Great Festival Hall of Hamburg City Hall. To mark its 60th anniversary, the Körber Foundation is increasing the prize endowment to one million euros as of this year. This makes the Körber Prize one of the world's most highly endowed research prizes. "We want to set an example for the recognition of top-class research in Europe," says Dr. Lothar Dittmer, Chairman of the Executive Board of the Körber Foundation, "and with our new stipulation that five percent of the prize money is to be used for science communication, we want to contribute to this recognition also growing in the public sphere." Every year since 1985, the Körber Foundation has honored a major breakthrough in the physical or life sciences in Europe. The prize is awarded to excellent and innovative research approaches with high application potential. To date, six prize winners have also been awarded the Nobel Prize after receiving the Körber Prize.

Managing the ups and downs of coffee production in Brazil

National Council for Scientific and Technological Development, Empresa de Pesquisa Agropecuaria de Minas Gerais

Each day, more than 2 billion cups of coffee are consumed worldwide.

Developing countries produce about 90% of the beans used to make all those lattes, espressos and mochas. That makes coffee a key source of revenue and livelihood for millions of people worldwide.

But coffee plants have up-and-down yield patterns. Years with high yields are often followed by years with low yields and vice-versa. This alternating pattern of high and low yields is called the "biennial effect".

"It's like physiological recovery," says Indalécio Cunha Vieira Júnior. "Coffee plants need to 'vegetate' for a year to produce well the following year." Cunha is a researcher at the Federal University of Lavras in Brazil. CAPTION This coffee bean plant of the cultivar 'Catigua' in its high production year. Catigua is one of the most commercially-grown cultivars in Brazil.  CREDIT César Elias Botelho{module In-article}

The biennial effect makes it challenging for coffee breeders to compare yields from different varieties of coffee. Without accurate measures of yield, breeders cannot know which varieties of coffee would be most useful for farmers to grow.

In a new study, Cunha and colleagues outline a computational model that compensates for the biennial effect in coffee. This model reduces experimental error. It also increases the usefulness of data obtained from field trials. In turn, the model directly impacts the quality of coffee varieties supplied to farmers.

"Ultimately, our findings could reduce the cost and time to launch a new coffee variety into the market by half," says Cunha.

The new model could also help farmers improve yields. "The model generates data on biennial growth at the level of individual coffee plants," says Cunha. Using information from the model, farmers could tailor cultivation strategies to individual plants. Effective management of growing conditions directly impacts harvest quality and yields.

The study also yielded some unexpected results. Researchers discovered that the biennial effect in coffee doesn't follow a well-defined pattern, as previously thought.

"Many researchers assumed that all coffee plants in an area would have similar yield patterns," says Cunha. But, researchers found that some coffee plants can have reasonably stable yields across years. Other plants may have high yields for two years and reduced yields in the third.

"These findings will change how coffee breeding experiments are analyzed," says Cunha.

The new model also allows researchers to determine why individual coffee plants may have high or low yields each year.

Some coffee plants with high yields may belong to high-yielding varieties. However, the plants of high-yielding varieties may produce low yields during recovery years.

"Our model enables us to delve deeper into the biennial effect," says Cunha. "This could allow us to recommend the most productive varieties for farmers with higher accuracy and lower costs."

Cunha and colleagues used a supercomputer simulation to test the effectiveness of their model. "The simulation allowed us to confirm our findings on real data," says Cunha. It also helped researchers test conditions in which the model performed well and when it ran into difficulties.

In general, "simulation results showed the model could effectively determine individual biennial stages," says Cunha. The new model was shown to be an improvement over older models.

Cunha is now trying to incorporate more genetic information into the current model. This would allow researchers to study the genetic control of the biennial effect. Understanding the genetic basis of the biennial effect could be very useful. For example, it might allow breeders to identify coffee varieties with more uniform yields across multiple years.

Coffee isn't the only crop to show biennial effects. Apple trees, for example, also exhibit biennial effects. Findings from Cunha's work could also apply to these other crop varieties.

Artificial intelligence could be 'game changer' in detecting, managing Alzheimer's disease

The study introduces machine learning as a new tactic in assessing cognitive brain health and patient care

Worldwide, about 44 million people are living with Alzheimer's disease (AD) or a related form of dementia. Although 82 percent of seniors in the United States says it's important to have their thinking or memory checked, only 16 percent say they receive regular cognitive assessments.

Many traditional memory assessment tools are widely available to health professionals, though deficiencies in screening and detection accuracy and reliability remain prevalent. But even with the increasingly favorable instrument MemTrax, a very simple online memory test using images recognition, the clinical efficacy of this new approach as a memory function screening tool has not been sufficiently demonstrated or validated. In practice, there are numerous integrated and complex factors to consider in interpreting memory evaluation test results, which presents a real challenge for clinicians. All these factors stand as a collective barrier to suitably addressing the growing and widespread prevalence of AD and those affected by the disease. A team of researchers at Florida Atlantic University's College of Engineering and Computer Science, SIVOTEC Analytics, HAPPYneuron, MemTrax, and Stanford University School of Medicine introduce supervised machine learning as a modern approach and new value-added complementary tool in cognitive brain health assessment and related patient care and management. {module In-article}

Could artificial intelligence be the solution for testing and managing this complex human health condition? A team of researchers at Florida Atlantic University's College of Engineering and Computer Science, SIVOTEC Analytics, HAPPYneuron, MemTrax, and Stanford University School of Medicine, think so and put their theory to the test.

The researchers employed a novel application of supervised machine learning and predictive modeling to demonstrate and validate the cross-sectional utility of MemTrax as a clinical decision support screening tool for assessing cognitive impairment.

Results of the study, published in the Journal of Alzheimer's Disease, introduce supervised machine learning as a modern approach and new value-added complementary tool in cognitive brain health assessment and related patient care and management.

Findings demonstrate the potential valid clinical utility of MemTrax, administered as part of the online Continuous Recognition Tasks (M-CRT) test, in screening for variations in cognitive brain health. Notably, a comparison of MemTrax to the recognized and widely utilized Montreal Cognitive Assessment Estimation of mild cognitive impairment underscores the power and potential of this new online tool and approach in evaluating short-term memory in diagnostic support for cognitive screening and assessment with a variety of clinical conditions and impairments including dementia.

"Machine learning has an inherent capacity to reveal meaningful patterns and insights from a large, complex inter-dependent array of clinical determinants and the ability to continue to 'learn' from ongoing utility of practical predictive models," said Taghi Khoshgoftaar, Ph.D., co-author and Motorola Professor in FAU's Department of Computer and Electrical Engineering and Computer Science. "Seamless use and real-time interpretation will enhance case management and patient care through innovative technology and practical and readily usable integrated clinical applications that could be developed into a hand-held device and app."

For the study, the researchers used an existing dataset (18,395) from HAPPYneuron. They examined answers to general health screening questions (addressing memory, sleep quality, medications, and medical conditions affecting thinking), demographic information, and test results from a sample of adults who took the MemTrax (M-CRT) test for episodic-memory screening. MemTrax performance and participant features were used as independent attributes: true positive/negative, percent responses/correct, response time, age, sex, and recent alcohol consumption. For predictive modeling, they used demographic information and test scores to predict the binary classification of the health-related questions (yes/no) and general health status (healthy/unhealthy), based on the screening questions.

"Findings from our study provide an important step in advancing the approach for clinically managing a very complex condition like Alzheimer's disease," said Michael F. Bergeron, Ph.D., senior author and senior vice president of development and applications, SIVOTEC Analytics. "By analyzing a wide array of attributes across multiple domains of the human system and functional behaviors of brain health, informed and strategically directed advanced data mining, supervised machine learning, and robust analytics can be integral, and in fact necessary, for health care providers to detect and anticipate further progression in this disease and myriad other aspects of cognitive impairment."

AD is the sixth leading cause of death in the United States, affecting 5.8 million Americans. According to the Alzheimer's Association, this number is projected to rise to 14 million by 2050. In 2019, AD and other dementias will cost the nation $290 billion. By 2050, these costs could rise as high as $1.1 trillion.

"With its widespread prevalence and escalating incidence and public health burden, it is imperative to ensure that the tools clinicians use for testing and managing Alzheimer's disease and other related cognitive conditions are optimal," said Stella Batalama, Ph.D., dean of FAU's College of Engineering and Computer Science. "Results from this important study provide new insights and discovery that has set the stage for future impactful and significant research."