Caption:This superconducting parametric amplifier can achieve quantum squeezing over much broader bandwidths than other designs, which could lead to faster and more accurate quantum measurements.
Caption:This superconducting parametric amplifier can achieve quantum squeezing over much broader bandwidths than other designs, which could lead to faster and more accurate quantum measurements.

MIT scientists boost quantum signals while reducing noise

“Squeezing” noise over a broad frequency bandwidth in a quantum system could lead to faster and more accurate quantum measurements.

A certain amount of noise is inherent in any quantum system. For instance, when researchers want to read information from a quantum supercomputer, which harnesses quantum mechanical phenomena to solve certain problems too complex for classical computers, the same quantum mechanics also imparts a minimum level of unavoidable error that limits the accuracy of the measurements. Caption:This image shows many Josephson traveling-wave parametric amplifiers on a silicon wafer. Chaining more than 3,000 of these devices together enabled the researchers to achieve broadband amplification and high levels of quantum squeezing.

Scientists can effectively get around this limitation by using “parametric” amplification to “squeeze” the noise –– a quantum phenomenon that decreases the noise affecting one variable while increasing the noise that affects its conjugate partner. While the total amount of noise remains the same, it is effectively redistributed. Researchers can then make more accurate measurements by looking only at the lower-noise variable.

A team of researchers from MIT and elsewhere has now developed a new superconducting parametric amplifier that operates with the gain of previous narrowband squeezers while achieving quantum squeezing over much larger bandwidths. Their work is the first to demonstrate squeezing over a broad frequency bandwidth of up to 1.75 gigahertz while maintaining a high degree of squeezing (selective noise reduction). In comparison, previous microwave parametric amplifiers generally achieved bandwidths of only 100 megahertz or less.

This new broadband device may enable scientists to read out quantum information much more efficiently, leading to faster and more accurate quantum systems. By reducing the error in measurements, this architecture could be utilized in multiqubit systems or other metrological applications that demand extreme precision.

“As the field of quantum computing grows, and the number of qubits in these systems increases to thousands or more, we will need broadband amplification. With our architecture, with just one amplifier you could theoretically read out thousands of qubits at the same time,” says electrical engineering and computer science graduate student Jack Qiu, who is a member of the Engineering Quantum Systems Group and lead author of the paper detailing this advance.

The senior authors are William D. Oliver, the Henry Ellis Warren professor of electrical engineering and computer science and physics, director of the Center for Quantum Engineering, and associate director of the Research Laboratory of Electronics; and Kevin P. O’Brien, the Emanuel E. Landsman Career Development professor of electrical engineering and computer science. 

Squeezing noise below the standard quantum limit

Superconducting quantum circuits, like quantum bits or “qubits,” process and transfer information in quantum systems. This information is carried by microwave electromagnetic signals comprising photons. But these signals can be extremely weak, so researchers use amplifiers to boost the signal level such that clean measurements can be made.

However, a quantum property known as the Heisenberg Uncertainty Principle requires a minimum amount of noise to be added during the amplification process, leading to the “standard quantum limit” of background noise. However, a special device, called a Josephson parametric amplifier, can reduce the added noise by “squeezing” it below the fundamental limit by effectively redistributing it elsewhere.

Quantum information is represented in the conjugate variables, for example, the amplitude and phase of electromagnetic waves. However, in many instances, researchers need only measure one of these variables — the amplitude or the phase — to determine the quantum state of the system. In these instances, they can “squeeze the noise,” lowering it for one variable, say amplitude, while raising it for the other, in this case, phase. The total amount of noise stays the same due to Heisenberg’s Uncertainty Principle, but its distribution can be shaped in such a way that less noisy measurements are possible on one of the variables.

A conventional Josephson parametric amplifier is resonator-based: It’s like an echo chamber with a superconducting nonlinear element called a Josephson junction in the middle. Photons enter the echo chamber and bounce around to interact with the same Josephson junction multiple times. In this environment, the system nonlinearity — realized by the Josephson junction — is enhanced and leads to parametric amplification and squeezing. But, since the photons traverse the same Josephson junction many times before exiting, the junction is stressed. As a result, both the bandwidth and the maximum signal the resonator-based amplifier can accommodate are limited.

The MIT researchers took a different approach. Instead of embedding a single or a few Josephson junctions inside a resonator, they chained more than 3,000 junctions together, creating what is known as a Josephson traveling-wave parametric amplifier. Photons interact with each other as they travel from junction to junction, resulting in noise squeezing without stressing any single­­­­­ junction.

Their traveling-wave system can tolerate much higher-power signals than resonator-based Josephson amplifiers without the bandwidth constraint of the resonator, leading to broadband amplification and high levels of squeezing, Qiu says.

“You can think of this system as a long optical fiber, another type of distributed nonlinear parametric amplifier. And, we can push to 10,000 junctions or more. This is an extensible system, as opposed to the resonant architecture,” he says.

Nearly noiseless amplification

A pair of pump photons enter the device, serving as the energy source. Researchers can tune the frequency of photons coming from each pump to generate squeezing at the desired signal frequency. For instance, if they want to squeeze a 6-gigahertz signal, they would adjust the pumps to send photons at 5 and 7 gigahertz, respectively. When the pump photons interact inside the device, they combine to produce an amplified signal with a frequency right in the middle of the two pumps. This is a special process of a more generic phenomenon called nonlinear wave mixing.

“Squeezing of the noise results from a two-photon quantum interference effect that arises during the parametric process,” he explains.

This architecture enabled them to reduce the noise power by a factor 10 below the fundamental quantum limit while operating with 3.5 gigahertz of amplification bandwidth — a frequency range that is almost two orders of magnitude higher than previous devices.

Their device also demonstrates the broadband generation of entangled photon pairs, which could enable researchers to read out quantum information more efficiently with a much higher signal-to-noise ratio, Qiu says.

While Qiu and his collaborators are excited by these results, he says there is still room for improvement. The materials they used to fabricate the amplifier introduce some microwave loss, which can reduce performance. Moving forward, they are exploring different fabrication methods that could improve the insertion loss.

“This work is not meant to be a standalone project. It has tremendous potential if you apply it to other quantum systems — to interface with a qubit system to enhance the readout, or entangle qubits, or extend the device operating frequency range to be utilized in dark matter detection and improve its detection efficiency. This is essentially like a blueprint for future work,” he says.

Additional co-authors include Arne Grimsmo, senior lecturer at the University of Sydney; Kaidong Peng, an EECS graduate student in the Quantum Coherent Electronics Group at MIT; Bharath Kannan, Ph.D. ’22, CEO of Atlantic Quantum; Benjamin Lienhard Ph.D. ’21, a postdoc at Princeton University; Youngkyu Sung, an EECS grad student at MIT; Philip Krantz, an MIT postdoc; Vladimir Bolkhovsky, Greg Calusine, David Kim, Alex Melville, Bethany Niedzielski, Jonilyn Yoder, and Mollie Schwartz, members of the technical staff at MIT Lincoln Laboratory; Terry Orlando, professor of electrical engineering at MIT and a member of RLE; Irfan Siddiqi, a professor of physics at the University of California at Berkeley; and Simon Gustavsson, a principal research scientist in the Engineering Quantum Systems group at MIT.  

This work was funded, in part, by the NTT Physics and Informatics Laboratories and the Office of the Director of National Intelligence IARPA program.

Accuracy of ChatGPT on USMLE. For USMLE Steps 1, 2CK, and 3, AI outputs were adjudicated to be accurate, inaccurate, or indeterminate based on the ACI scoring system provided in S2 Data. A: Accuracy distribution for inputs encoded as open-ended questions. B: Accuracy distribution for inputs encoded as multiple choice single answer without (MC-NJ) or with forced justification (MC-J).
Accuracy of ChatGPT on USMLE. For USMLE Steps 1, 2CK, and 3, AI outputs were adjudicated to be accurate, inaccurate, or indeterminate based on the ACI scoring system provided in S2 Data. A: Accuracy distribution for inputs encoded as open-ended questions. B: Accuracy distribution for inputs encoded as multiple choice single answer without (MC-NJ) or with forced justification (MC-J).

ChatGPT can almost pass the US Medical Licensing Exam

AI software was able to achieve passing scores for the exam, which usually requires years of medical training

ChatGPT can score at or around the approximately 60 percent passing threshold for the United States Medical Licensing Exam (USMLE), with responses that make coherent, internal sense and contain frequent insights, according to a study published February 9, 2023, in the open-access journal PLOS Digital Health by Tiffany Kung, Victor Tseng, and colleagues at AnsibleHealth.

ChatGPT is a new artificial intelligence (AI) system, known as a large language model (LLM), designed to generate human-like writing by predicting upcoming word sequences. Unlike most chatbots, ChatGPT cannot search the internet. Instead, it generates text using word relationships predicted by its internal processes.

Kung and colleagues tested ChatGPT’s performance on the USMLE, a highly standardized and regulated series of three exams (Steps 1, 2CK, and 3) required for medical licensure in the United States. Taken by medical students and physicians-in-training, the USMLE assesses knowledge spanning most medical disciplines, ranging from biochemistry, to diagnostic reasoning, to bioethics.

After screening to remove image-based questions, the authors tested the software on 350 of the 376 public questions available from the June 2022 USMLE release. 

After indeterminate responses were removed, ChatGPT scored between 52.4% and 75.0% across the three USMLE exams. The passing threshold each year is approximately 60%. ChatGPT also demonstrated 94.6% concordance across all its responses and produced at least one significant insight (something that was new, non-obvious, and clinically valid) for 88.9% of its responses. Notably, ChatGPT exceeded the performance of PubMedGPT, a counterpart model trained exclusively on biomedical domain literature, which scored 50.8% on an older dataset of USMLE-style questions.

While the relatively small input size restricted the depth and range of analyses, the authors note their findings provide a glimpse of ChatGPT’s potential to enhance medical education, and eventually, clinical practice. For example, they add, clinicians at AnsibleHealth already use ChatGPT to rewrite jargon-heavy reports for easier patient comprehension.

“Reaching the passing score for this notoriously difficult expert exam, and doing so without any human reinforcement, marks a notable milestone in clinical AI maturation,” say the authors.

Author Dr. Tiffany Kung added that ChatGPT's role in this research went beyond being the study subject: "ChatGPT contributed substantially to the writing of [our] manuscript... We interacted with ChatGPT much like a colleague, asking it to synthesize, simplify, and offer counterpoints to drafts in progress...All of the co-authors valued ChatGPT's input."

Ritwik Kulkarni et al. 2023
Ritwik Kulkarni et al. 2023

University of Helsinki AI methods tackle the illegal wildlife trade on the Internet

In Finland, scientists applied machine vision models and were able to deduce from the context of an image if it pertained to the sale of a live animal. These methods make it possible to flag the posts which may be selling animals illegally.

Illegal wildlife trade is estimated to be a multi-billion dollar industry where hundreds of species are traded globally. A considerable proportion of the illegal wildlife trade now uses online marketplaces to advertise and sell live animals or animal products as it can reach more buyers than previously possible. With the trade happening across the Internet, it is extremely challenging to manually search through thousands of posts, and methods for automated filtering are needed.

Compared to using computer vision to identify species from images, the identification of images related to the illegal wildlife trade of species is rendered difficult by the need to identify the context in which the species are portrayed.

In a new article published in Biological Conservation, scientists based at the Helsinki Lab of Interdisciplinary Conservation Science, University of Helsinki, Finland, have filled this gap and developed an automated algorithm using machine learning to identify such image content in the digital space.

“This is the first-time machine vision models have been applied to deduce the context of an image to identify the sale of a live animal. When a seller is advertising an animal for sale, many times the advertisement is accompanied by an image of the animal in a captive state. This differs from non-captive images, for example, a picture of an animal taken by a tourist in a national park. Using a technique called feature visualization, we demonstrated that our models could take into account both the presence of an animal in the image and the surrounding environment of the animal in the image. Thus, making it possible to flag the posts which may be selling animals illegally.” says Dr. Ritwik Kulkarni, the lead author of this study.

As part of their research, scientists trained 24 different neural-net models on a newly created dataset, under various experimental conditions. The top-performing models achieved very high accuracy and were able to discern well between natural and captive contexts. Another interesting feature of the study is that the models were also tested and performed well on data acquired from a source unrelated to training data, therefore showing the capability to work well for the identification of other content on the Internet.                    

“These methods are a game changer in our work that seeks to enhance automated identification of illegal wildlife trade content from digital sources. We are now upscaling this work to include more taxonomic groups beyond mammals and to develop new models that can identify image and text content simultaneously.”, says Associate Professor Enrico Di Minin, the other co-author who heads the Helsinki Lab of Interdisciplinary Conservation Science.

The scientists are planning to make their methods openly available for the use of the broader scientific and practitioners’ community.